Clinical utility of objective tests for dry eye disease: variability over time and implications for clinical trials and disease management
Clinical utility of objective tests for dry eye disease: variability over time and implications for clinical trials and disease management
This study evaluates the efficacy of commonly used biomarkers in dry eye disease management in a longitudinal observational case series study followed by an interventional study in a subset of subjects treated with cyclosporine A (0.05%).

This study evaluates the efficacy of commonly used biomarkers in dry eye disease management in a longitudinal observational case series study followed by an interventional study in a subset of subjects treated with cyclosporine A (0.05%). Over a 3-month period, tear film osmolarity was found to have the lowest variability among commonly used signs of dry eye disease. Reductions in osmolarity preceded changes in symptoms during therapy.

Author: Sullivan BD, Crews LA, Sönmez B, et al

Source: Cornea. 2012 Sep;31(9):1000-8.

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