This study evaluates the efficacy of commonly used biomarkers in dry eye disease management in a longitudinal observational case series study followed by an interventional study in a subset of subjects treated with cyclosporine A (0.05%). Over a 3-month period, tear film osmolarity was found to have the lowest variability among commonly used signs of dry eye disease. Reductions in osmolarity preceded changes in symptoms during therapy.
Author: Sullivan BD, Crews LA, Sönmez B, et al
Source: Cornea. 2012 Sep;31(9):1000-8.