Importance of Diagnosis

In a prevalence study conducted with over 9000 patients:

61% of overall population with abnormal osmolarity

Of those that had abnormal osmolarity, 59% of the patients reported having at least three DED symptoms

  • Average osmolarity of patients with abnormal osmolarity (≥308 mOsm/L) or inter-eye difference (≥8 mOsm/L) = 318 mOsm/L

  • Average osmolarity of patients with normal osmolarity (≤308 mOsm/L) or inter-eye difference (≤8 mOsm/L)  = 297 mOsm/L

Abnormal osmolarity can effect pre-surgical keratometry measurements

Patients with abnormal osmolarity were defined, within the protocol, as osmolarity ≥ 316 mOsm/L

Can abnormal osmolarity impact surgical outcomes?

17%

17% of eyes with abnormal osmolarity had >1 D (diopter) of difference in keratometry cylinder values between two pre-surgical visits

10%

10% of eyes with abnormal osmolarity had >0.5 D (diopter) of change in calculated IOL power

Play
Effects of Osmolarity on the Repeatability of Keratometry in Patients Presenting for Cataract Surgery

Contact Lens Dropout

Abnormal osmolarity can play a role

A STUDY PRESENTED AT AAO†Found: 

All patients with contact lens discomfort and <8 hours of daily wear time had abnormal osmolarity.†

These patients were put on a treatment to reduce osmolarity levels, resulting in an average increase of 4.6 hours in daily contact lens wear time.†

Symptoms alone may not determine the cause of contact lens discomfort. Consider abnormal tear osmolarity as a potential reason.†

                                                                            60 Percent of symptomatic patients had abnormal tear osmolarity.
of symptomatic patients had abnormal tear osmolarity.
                                                                           56 Percent of asymptomatic patients had abnormal tear osmolarity.
of asymptomatic patients had abnormal tear osmolarity.

MANAGE

Use TearLab osmolarity data to inform your treatment plan based on disease severity and manage patient progress by evaluating therapeutic effectiveness.†

 

Response to Therapy: Abnormal osmolarity decreases with effective treatment

Cyclosporine Treatment Chart

HP Guar Treatment chart

Omega-3 Treatment Chart

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